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. 1994 Sep 15;54(3):286-8.
doi: 10.1002/ajmg.1320540319.

Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease

G Lucotte  1 , S Visvikis, B Leininger-Müler, F David, S Berriche, S Réveilleau, R Couderc, M C Babron, D Aguillon, G Siest
Affiliations

Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease

G Lucotte et al. Am J Med Genet. .

Abstract

Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.

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