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. 1994 Sep;38(9):2175-9.
doi: 10.1128/AAC.38.9.2175.

Substrate specificity of Epstein-Barr virus thymidine kinase

P P Tung  1 , W C Summers
Affiliations

Substrate specificity of Epstein-Barr virus thymidine kinase

P P Tung et al. Antimicrob Agents Chemother. 1994 Sep.

Abstract

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.

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