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Comparative Study
. 1994 Sep;38(9):2191-3.
doi: 10.1128/AAC.38.9.2191.

Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus

C M Brandt  1 , M S Rouse, B M Tallan, W R Wilson, J M Steckelberg
Affiliations
Comparative Study

Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus

C M Brandt et al. Antimicrob Agents Chemother. 1994 Sep.

Abstract

Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. For rifampin-cephalosporin combinations, in vitro synergy testing using recommended fractions of the MIC failed to predict antagonism in vivo while concentrations above the MIC corresponded with antagonism in vivo.

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