Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Aug;8(4):433-40.
doi: 10.1007/BF00125377.

Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

Y P Pang  1 , J Zaidi, A P Kozikowski, B Cusack, E Richelson
Affiliations

Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

Y P Pang et al. J Comput Aided Mol Des. 1994 Aug.

Abstract

We report the rational design of novel neurotensin mimetics through use of the Multiple Template Approach. This approach is based on our notion that a flexible peptide can be replaced by a partially flexible molecule, identified through testing a comparatively small number of molecules possessing a different intrinsic availability of conformations of the native peptide. The Multiple Template Approach has culminated in the discovery of a pharmacologically unprecedented agent, which behaves as a neurotensin antagonist at low concentration and as a full neurotensin agonist at high concentration.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Synapse. 1991 Nov;9(3):225-30 - PubMed
    1. Biochem Pharmacol. 1988 Jul 15;37(14):2833-8 - PubMed
    1. Biochem Pharmacol. 1991 Nov 27;42(12):2265-74 - PubMed
    1. Biochem Pharmacol. 1986 Feb 1;35(3):391-7 - PubMed
    1. J Neurochem. 1986 Oct;47(4):1214-8 - PubMed

Publication types