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. 1995 Jan 12;373(6510):123-6.
doi: 10.1038/373123a0.

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

D D Ho  1 , A U Neumann, A S Perelson, W Chen, J M Leonard, M Markowitz
Affiliations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

D D Ho et al. Nature. .

Abstract

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

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