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. 1995 Jan;71(1):64-8.
doi: 10.1038/bjc.1995.13.

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1

J Adélaide  1 , G Monges, C Dérdérian, J F Seitz, D Birnbaum
Affiliations
Free PMC article

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1

J Adélaide et al. Br J Cancer. 1995 Jan.
Free PMC article

Abstract

The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.

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