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. 1994 Oct 3;659(1-2):226-30.
doi: 10.1016/0006-8993(94)90883-4.

TNF-alpha increases the frequency of spontaneous miniature synaptic currents in cultured rat hippocampal neurons

F Grassi  1 , A M Mileo, L Monaco, A Punturieri, A Santoni, F Eusebi
Affiliations

TNF-alpha increases the frequency of spontaneous miniature synaptic currents in cultured rat hippocampal neurons

F Grassi et al. Brain Res. .

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a cytokine secreted by activated astrocytes and is known to alter evoked synaptic activity in slices of adult rat hippocampus. In this paper we show that TNF-alpha increases the frequency of spontaneous miniature synaptic currents in cultured hippocampal neurons, acting at nanomolar concentrations. In addition, we show that the mRNA for the 55 kDa TNF-alpha receptor (TNF-R1) is detected in embryonic rat hippocampal cultures, as well as in acutely dissected embryonic and adult rat hippocampi. Possible transduction pathways mediating the TNF-alpha effect are discussed.

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