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. 1978 Jul 1;2(8079):17-8.
doi: 10.1016/s0140-6736(78)91325-9.

Inhibition of active-transport sodium-potassium-A.T.P.ase by myeloma protein

J McGeoch, J Falconer Smith, J Ledingham, B Ross

Inhibition of active-transport sodium-potassium-A.T.P.ase by myeloma protein

J McGeoch et al. Lancet. .

Abstract

Patients with multiple myeloma excrete immunoglobulin light chain (Bence-Jones protein) in the urine. Light chain accumulates in the nephron, and this may result in renal disease, which accounts for the death of between 1 in 4 and 1 in 7 patients with multiple myeloma. Myeloma light chain inhibits transport of paraaminohippurate in the kidney. Evidence is presented here that light chain affects renal transport by inhibiting the active-transport enzyme, ouabain-sensitive Na-K-A.T.P.ase. As a direct consequence, renal A.T.P. content and the maximum rate of gluconeogenesis from lactate are enhanced in the presence of light chain.

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