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Clinical Trial
. 1995 Feb;63(2):707-9.
doi: 10.1128/iai.63.2.707-709.1995.

Attenuated live cholera vaccine strain CVD 103-HgR elicits significantly higher serum vibriocidal antibody titers in persons of blood group O

R Lagos  1 , A Avendaño, V Prado, I Horwitz, S Wasserman, G Losonsky, S Cryz Jr, J B Kaper, M M Levine
Affiliations
Clinical Trial

Attenuated live cholera vaccine strain CVD 103-HgR elicits significantly higher serum vibriocidal antibody titers in persons of blood group O

R Lagos et al. Infect Immun. 1995 Feb.

Abstract

Persons of blood group O are at increased risk of developing cholera gravis. In a randomized, placebo-controlled, double-blind safety-immunogenicity trial of live oral cholera vaccine CVD 103-HgR in 5- to 9-year-old Chilean children, vibriocidal antibody seroconversion (74% overall) did not differ by blood group. However, the reciprocal geometric mean titer (GMT) in blood group O vaccines (GMT = 486) was higher than that in non-O vaccines (GMT = 179) (P < 0.02).

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