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Review
. 1994 Oct;5(8):698-701.
doi: 10.1093/oxfordjournals.annonc.a058972.

Immunoconjugates: lessons from animal models

S Canevari  1 , M Colombatti, M I Colnaghi
Affiliations
Free article
Review

Immunoconjugates: lessons from animal models

S Canevari et al. Ann Oncol. 1994 Oct.
Free article

Abstract

Monoclonal antibody-mediated cancer therapy has evolved through a challenging chain of problems and solutions. The very limited therapeutic success obtained with unarmed monoclonal antibodies has increased the interest in different antibody-based targeting strategies, and numerous preclinical and even clinical studies with immunoconjugates have now been conducted. We comment here on the messages implicit in a recent report on a doxorubicin-anti-carcinoma antibody conjugate and from several other studies.

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