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Review
. 1993;112(1 Suppl):S35-9.
doi: 10.1007/BF02245005.

Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

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Review

Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

T Hashimoto et al. Psychopharmacology (Berl). 1993.

Abstract

Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.

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References

    1. J Neurosci. 1992 Feb;12(2):440-53 - PubMed
    1. Behav Neural Biol. 1991 Mar;55(2):214-26 - PubMed
    1. J Neural Transm Gen Sect. 1991;85(1):19-29 - PubMed
    1. Eur J Pharmacol. 1989 Feb 14;161(1):45-51 - PubMed
    1. Arch Gen Psychiatry. 1988 Sep;45(9):789-96 - PubMed

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