Plasticity of excitatory synaptic transmission in kitten visual cortex depends on voltage-dependent Ca2+ channels but not on NMDA receptors
- PMID: 7838421
- DOI: 10.1016/0168-0102(94)90089-2
Plasticity of excitatory synaptic transmission in kitten visual cortex depends on voltage-dependent Ca2+ channels but not on NMDA receptors
Abstract
Long-term potentiation (LTP) of excitatory synaptic transmission occurs in in vitro slices of cat and rat visual cortex. Earlier studies suggested that activation of N-methyl-D-aspartate (NMDA)-selective glutamate receptors is essential for the induction of LTP. However, our studies on kitten visual cortex demonstrate that LTP induction requires the activation of low-threshold Ca2+ channels in postsynaptic cells but not of NMDA receptors.
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