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. 1994 Oct;38(10):2458-9.
doi: 10.1128/AAC.38.10.2458.

Biocidal action of chlorhexidine is annulled by nicotinic acid

H Baker  1 , O Frank, B DeAngelis, E R Baker
Affiliations

Biocidal action of chlorhexidine is annulled by nicotinic acid

H Baker et al. Antimicrob Agents Chemother. 1994 Oct.

Abstract

An analytical system comprising a bacterium and a protozoan was used to pinpoint the metabolic lesion whereby chlorhexidine (CLX) produced cell death. Nicotinic acid but not nicotinamide annulled the biocidal action of CLX. The results suggest that CLX may not permit bioconversion of nicotinamide to nicotinic acid to annul the growth inhibition induced by CLX.

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