Review
. 1994;149(3-4):181-90; discussion 190-4.
[Insulin receptors and mechanism of action of insulin and of insulin-like growth factors]
[Article in
French]
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- PMID: 7841929
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Review
[Insulin receptors and mechanism of action of insulin and of insulin-like growth factors]
[Article in
French]
Bull Mem Acad R Med Belg.
1994.
Abstract
A novel mechanism of activation of the insulin and IGF-I receptors by their respective ligands is proposed, whereby the bivalent ligand bridges the two receptor alpha subunits at opposite sites in a symmetrical receptor structure. The proposed mechanism accounts for the binding stoichiometry and the phenomenon of negative cooperativity. It may play an important role in the regulation of mitogenesis.
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