Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov;232(11):683-8.
doi: 10.1007/BF00171385.

Hamster Greene melanoma in the rabbit eye: immunosuppressive treatment to improve this tumor model

I de Waard-Siebinga  1 , J L van Delft, D de Wolff-Rouendaal, M Jager
Affiliations

Hamster Greene melanoma in the rabbit eye: immunosuppressive treatment to improve this tumor model

I de Waard-Siebinga et al. Graefes Arch Clin Exp Ophthalmol. 1994 Nov.

Abstract

Background: The hamster Greene melanoma (HGM) implanted in the anterior chamber of the rabbit eye has been used to study experimental therapies for human uveal melanoma. However, the occurrence of spontaneous necrosis limits the value of this model for long-term evaluation of experimental treatments. In the present study we tested the hypothesis that an immune response is the cause of this necrosis and that prevention of the immune response can prolong the experimentation time

Methods: HGM was implanted in the anterior chamber of control, presensitized and immunosuppressed rabbits. The effects of sensitization and immunosuppression were assessed by clinical and histological observation

Results: Sensitization led to a significant slowing down of tumor growth, but not to a difference in necrosis. Immunosuppressive treatment with cyclosporin A improved the success rate of implantation and decreased the amount of necrosis in the tumor

Conclusion: The immune response plays a role in the occurrence of necrosis. However, although immunosuppressive treatment with cyclosporin A decreased the amount of necrosis, significant necrosis still occurred, suggesting that other factors like angiogenesis play a part as well and still limit the usefulness of this model in the long-term evaluation of experimental therapies.

PubMed Disclaimer

References

    1. Arch Ophthalmol. 1992 Mar;110(3):405-7 - PubMed
    1. Adv Immunol. 1990;48:191-226 - PubMed
    1. Jpn J Ophthalmol. 1989;33(2):212-20 - PubMed
    1. Ophthalmic Res. 1992;24(2):119-24 - PubMed
    1. Cancer Res. 1949 Dec;9(12):728-35, illust - PubMed

LinkOut - more resources