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. 1994 Dec;47(12):1395-401.
doi: 10.7164/antibiotics.47.1395.

Isolation and characterization of a new 12-membered macrolide FD-895

M Seki-Asano  1 , T Okazaki, M Yamagishi, N Sakai, Y Takayama, K Hanada, S Morimoto, A Takatsuki, K Mizoue
Affiliations
Free article

Isolation and characterization of a new 12-membered macrolide FD-895

M Seki-Asano et al. J Antibiot (Tokyo). 1994 Dec.
Free article

Abstract

During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample collected at Iriomote Island, Okinawa prefecture, Japan. FD-895 showed stronger cytocidal activities against in vitro tumor cell lines than adriamycin. FD-895 had the same IC50 values against parent and adriamycin resistant HL-60 cells.

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