Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Feb 9;373(6514):487-93.
doi: 10.1038/373487a0.

The structural basis of specific base-excision repair by uracil-DNA glycosylase

R Savva  1 , K McAuley-Hecht, T Brown, L Pearl
Affiliations

The structural basis of specific base-excision repair by uracil-DNA glycosylase

R Savva et al. Nature. .

Abstract

The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes simplex virus type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and with uracil, define the DNA-binding site and allow a detailed understanding of the exquisitely specific recognition of uracil in DNA. The overall structure suggests binding models for elongated single- and double-stranded DNA substrates. Conserved residues close to the uracil-binding site suggest a catalytic mechanism for hydrolytic base excision.

PubMed Disclaimer

Publication types

LinkOut - more resources