Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Oct;350(4):393-7.
doi: 10.1007/BF00178957.

Convulsant action of a benzodiazepine receptor agonist/inverse agonist Ro 19-4603 in developing rats

H Kubová  1 , P Mares
Affiliations

Convulsant action of a benzodiazepine receptor agonist/inverse agonist Ro 19-4603 in developing rats

H Kubová et al. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct.

Abstract

An inverse benzodiazepine receptor agonist Ro 19-4603, administered intraperitoneally, was found to induce two types of motor seizures, i.e. minimal, predominantly clonic and major, generalized tonic-clonic, in rats at all developmental stages studied (7, 12, 18 and 25 days old). The developmental profile of the two types of seizure was different. Minimal seizures could be induced easily in the two youngest groups, whereas there were no marked differences in the induction of major seizures between the age groups. A lethal outcome was more common in 18- and 25-day-old rats than in younger animals. The convulsant action of the benzodiazepine agonist/inverse agonist Ro 19-4603 shows only quantitative changes during post-natal development in the rat.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Eur J Pharmacol. 1992 Jan 14;225(1):63-8 - PubMed
    1. Physiol Res. 1991;40(6):577-84 - PubMed
    1. Int Rev Neurobiol. 1975;17:1-36 - PubMed
    1. J Neurochem. 1979 Feb;32(2):655-8 - PubMed
    1. Life Sci. 1985 Dec 9;37(23):2205-11 - PubMed

Publication types

LinkOut - more resources