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Clinical Trial
. 1994 Nov;18(7):1121-7.
doi: 10.1016/0278-5846(94)90115-5.

Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

H C Charles  1 , F Lazeyras, K R Krishnan, O B Boyko, M Payne, D Moore
Affiliations
Clinical Trial

Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

H C Charles et al. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov.

Abstract

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

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