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Review
. 1994 Oct;2(10):343-7.
doi: 10.1016/0966-842x(94)90608-4.

Origin and evolution of DNA associated with resistance to methicillin in staphylococci

G L Archer  1 , D M Niemeyer
Affiliations
Review

Origin and evolution of DNA associated with resistance to methicillin in staphylococci

G L Archer et al. Trends Microbiol. 1994 Oct.

Abstract

The gene mediating resistance to methicillin in staphylococci (mecA) and its flanking sequences (mec DNA) make up a chromosomal DNA locus that is unique to methicillin-resistant bacteria; no equivalent locus exists in methicillin-susceptible cells. The origin of mec DNA is not known, but evidence supports horizontal transfer of mec DNA between different staphylococcal species and of the mecA gene between different Gram-positive genera.

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