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. 1994 Oct;2(10):361-6.
doi: 10.1016/0966-842x(94)90612-2.

Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics

C G Dowson  1 , T J Coffey, B G Spratt
Affiliations

Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics

C G Dowson et al. Trends Microbiol. 1994 Oct.

Abstract

Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.

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