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. 1994 Nov;138(3):787-90.
doi: 10.1093/genetics/138.3.787.

Dosage compensation in sciarids is achieved by hypertranscription of the single X chromosome in males

P R da Cunha  1 , B Granadino, A L Perondini, L Sánchez
Affiliations

Dosage compensation in sciarids is achieved by hypertranscription of the single X chromosome in males

P R da Cunha et al. Genetics. 1994 Nov.

Abstract

Dosage compensation refers to the process whereby females and males with different doses of sex chromosomes have similar amounts of products from sex chromosome-linked genes. We analyzed the process of dosage compensation in Sciara ocellaris, Diptera of the suborder Nematocera. By autoradiography and measurements of X-linked rRNA in females (XX) and males (XO), we found that the rate of transcription of the single X chromosome in males is similar to that of the two X chromosomes in females. This, together with the bloated appearance of the X chromosome in males, support the idea that in sciarids dosage compensation is accomplished by hypertranscription of the X chromosome in males.

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