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Clinical Trial
. 1995 Feb 18;345(8947):421-2.
doi: 10.1016/s0140-6736(95)90403-4.

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

B Myrup  1 , P M Hansen, T Jensen, A Kofoed-Enevoldsen, B Feldt-Rasmussen, J Gram, C Kluft, J Jespersen, T Deckert
Affiliations
Clinical Trial

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

B Myrup et al. Lancet. .

Abstract

We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.

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