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Clinical Trial
. 1976 Jun;52(608):379-80.
doi: 10.1136/pgmj.52.608.379.

Assessment of vaccine efficacy by challenge studies in man

D A Tyrrell
Clinical Trial

Assessment of vaccine efficacy by challenge studies in man

D A Tyrrell. Postgrad Med J. 1976 Jun.

Abstract

The only final test of the potency of a vaccine is its ability to protect against exposure in an epidemic. Laboratory tests for control purposes attempt to predict this capacity. It is suggested that challenging small groups of volunteers with attenuated influenza virus is a good index of immunity which could be used to check and refine present tests and to evaluate new ones.

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References

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    1. J Hyg (Lond). 1972 Sep;70(3):531-43 - PubMed
    1. Microbios. 1973 Sep-Oct;8(30):101-10 - PubMed
    1. Arch Virol. 1975;48(4):307-16 - PubMed

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