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. 1994;95(1):71-4.
doi: 10.1007/BF01283032.

Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release

K Svensson  1 , A Carlsson, N Waters
Affiliations

Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release

K Svensson et al. J Neural Transm Gen Sect. 1994.

Abstract

The dopamine D3 preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

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