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. 1994 Nov;26(2):281-90.
doi: 10.1006/brcg.1994.1063.

Comments on immune aspects of the Geschwind-Behan-Galaburda model and of the article of Bryden, McManus, and Bulman-Fleming

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Comments on immune aspects of the Geschwind-Behan-Galaburda model and of the article of Bryden, McManus, and Bulman-Fleming

A St-Marseille et al. Brain Cogn. 1994 Nov.

Abstract

The goal of this article is to reconsider the links among immune disorders, testosterone, and left-handedness made originally by Geschwind and Behan (1982) and by Geschwind and Galaburda (1985). We demonstrate that an excess of testosterone in utero is not a prerequisite for immune disorders, because of its destructive action on thymus, and that allergy and autoimmune disorders are not primarily thymo-dependent but B-lymphocyte-dependent. We furthermore study the HLA proposed by Yeo and Gangestad (1993) and retained by Bryden, McManus, and Bulman-Fleming as a possible variable that could explain, in replacement of testosterone, the link among allergy, asthma, and ulcerative colitis. We conclude that the HLA of lefthanders and the meta-analysis of Bryden et al. do not fit together as well as hoped for.

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