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. 1976 Jul;6(4):479-82.
doi: 10.1007/BF01973263.

Suramin stimulates B-lymphocyte proliferation in the mouse

T L Vischer

Suramin stimulates B-lymphocyte proliferation in the mouse

T L Vischer. Agents Actions. 1976 Jul.

Abstract

Suramin, a drug against trypanosomiasis and onchocerciasis, stimulates in vitro mouse B-lymphocytes to transform into blastcells, to incorporate 3H-thymidine and to go into mitosis. Thymus cells (hydro-cortisone-sensitive or resistant) do not respond whereas cells from homozygous nude mice are stimulated. The large majority of the blast-cells have surface immunoglobulins, and the proportion of cells with intracellular immunoglobulin increases during the course of the cultures.

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References

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