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Comparative Study
. 1994 Oct 26;139(2):117-21.
doi: 10.1007/BF01081734.

Catalytic roles of the AMP at the 3' end of tRNAs

N S Wickramasinghe  1 , J C Lacey Jr
Collaborators, Affiliations
Comparative Study

Catalytic roles of the AMP at the 3' end of tRNAs

N S Wickramasinghe et al. Mol Cell Biochem. .

Abstract

Recent reports suggest that the ribosome retains considerable peptidyl transferase activity even when much of the protein of the ribosome is removed and further suggests that rRNA may be the peptidyl transferase. The work here suggests that the AMP residue at the 3' terminus of each tRNA has some catalytic activity both in the esterification reaction and in forming a pseudopeptide, AcGly, and further suggests that whatever peptidyl transferase is, it finds a cooperative substrate in the aminoacyl-AMP at the 3' terminus of tRNA.

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References

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