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. 1995 Feb 17;267(5200):1016-8.
doi: 10.1126/science.7863326.

Peptide specificity in the recognition of MHC class I by natural killer cell clones

M S Malnati  1 , M Peruzzi, K C Parker, W E Biddison, E Ciccone, A Moretta, E O Long
Affiliations

Peptide specificity in the recognition of MHC class I by natural killer cell clones

M S Malnati et al. Science. .

Abstract

Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

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