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. 1976 Sep;25(3):383-8.

A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis

A J Fairfax, D Doniach, C E Wells

A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis

A J Fairfax et al. Clin Exp Immunol. 1976 Sep.

Abstract

A new antibody reacting with a cell membrane-related antigen is described in a patient with myasthenia gravis and chronic liver disease. The antibody gave a striking peripheral immunofluorescence in all cells tested and did not react with smooth muscle fibres, being distinct from anti-actin and anti-myosin antibodies. The antigen was widely distributed in human and animal tissues. The exact relationship of this antibody to the clinical condition is not obvious but its presence is further evidence of widespread disturbances of humoral immunity in myasthenia gravis.

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