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Case Reports
. 1994 Oct;72(10):769-71.
doi: 10.1007/BF00180544.

Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus

T Höhler  1 , G Teuber, R Wanitschke, K H Meyer zum Büschenfeld
Affiliations
Case Reports

Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus

T Höhler et al. Clin Investig. 1994 Oct.

Abstract

Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.

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