[Preliminary clinical study on prevention of bone loss in postmenopausal women with kidney invigoration]

Abstract

The effect of Bushen Migu Ye (BSMGY) on preventing the bone loss in postmenopausal women was observed. 43 healthy women with the menopause within 5 years were randomly divided into the treated and control groups, which were basically similar in age and menopausal time. BSMGY and Rhizoma Dioscoreae decoction was given orally in two groups. Some biochemical parameters related to bone metabolism, serum estradiol and forearm bone density were taken before and after treatment. The results showed that 5 months after BSMGY treatment, the ulnar and radial bone mineral content was higher than that of pretreatmental value (P < 0.05), while in control group this index was continually decreased. The change in bone density were also significant different (P < 0.05). It seems that BSMGY is able to prevent the bone loss in postmenopausal women. In the treated group, ratio of fasting urinary calcium and hydroxyproline to creatinine was lower than that of before treatment and the control group (P < 0.05); the concentration of serum alkaline phosphatase had no significant difference (P < 0.05). This preliminary study suggested that one of the therapeutic mechanism of BSMGY was probably due to declining of bone resorption, without affecting the bone formation in postmenopausal women.