Review
doi: 10.1016/0966-842x(94)90803-6.
The 5' noncoding region and virulence of poliovirus vaccine strains
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- PMID: 7866703
- DOI: 10.1016/0966-842x(94)90803-6
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Review
The 5' noncoding region and virulence of poliovirus vaccine strains
Trends Microbiol.
1994 Nov.
Abstract
All three live, attenuated vaccine strains of poliovirus contain important attenuation determinants in a short conserved sequence in the 5' noncoding region. Evidence suggests these act by weakening a secondary-structural element critical for the unusual mechanism of translational initiation of picornaviruses, in which ribosomes bind directly to a site far downstream of the 5' end. Understanding the molecular basis of attenuation may allow novel vaccine strains to be designed.
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