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Comparative Study
. 1995 Feb 28;92(5):1664-8.
doi: 10.1073/pnas.92.5.1664.

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens

T K McDaniel  1 , K G Jarvis, M S Donnenberg, J B Kaper
Affiliations
Comparative Study

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens

T K McDaniel et al. Proc Natl Acad Sci U S A. .

Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

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