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. 1976 Sep;3(9):2379-86.
doi: 10.1093/nar/3.9.2379.

Arangement of transfer-RNA -genes in yeast

H Feldman
Free PMC article

Arangement of transfer-RNA -genes in yeast

H Feldman. Nucleic Acids Res. 1976 Sep.
Free PMC article

Abstract

The redundancy and the arrangement of the genes for specific transfer ribonucleic acids in yeast were studied by the hybridization techniques developed by Birnstiel et al., e.g.[1]. The redundancy was found to be in the order of 10 genes for tRNA1Met, tRNA3Met, tRNA2Ser, and tRNA-Pro. High molecular weight yeast DNA was fractionated by density gradient centrifugation in cesium chloride and the [32p]tRNAs were hybridized to the single fractions. The results together with earlier findings [2] suggest that the cistrons for these tRNAs are arranged in tandem interspersed by 6 to 10 times longer segments of spacer DNA which varies in (G+C) content for the different tRNA species.

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References

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