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Review
. 1994;76(9):815-21.
doi: 10.1016/0300-9084(94)90182-1.

Determinants of translational fidelity and efficiency in vertebrate mRNAs

M Kozak  1
Affiliations
Review

Determinants of translational fidelity and efficiency in vertebrate mRNAs

M Kozak. Biochimie. 1994.

Abstract

This article reviews current knowledge on the mechanisms affecting the fidelity of initiation codon selection, and discusses the effects of structural features in the 5′-non-coding region on the efficiency of translation of messenger RNA molecules.

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References

    1. Kozak M. The scanning model for translation: an update. J Cell Biol. 1989;108:229–241. - PMC - PubMed
    1. Kozak M. A consideration of alternative models for the initiation of translation in eukaryotes. Crit Rev Biochem Mol Biol. 1992;27:385–402. - PubMed
    1. Bigler J., Hokanson W., Eisenman R.N. Thyroid hormone receptor transcriptional activity is potentially autoregulated by truncated forms of the receptor. Mol Cell Biol. 1992;12:2406–2417. - PMC - PubMed
    1. Feyen J.H.M., Cardinauv F., Gamse R., Bruns C., Azria M., Trechsel U. N-terminal truncation of salmon calcitonin leads to the calcitonin antagonists. Biochem Biophys Res Commun. 1992;187:8–13. - PubMed
    1. Ledley F.D., Jansen R., Nham S., Fenton W.A., Rosenberg L.E. Vol. 87. 1990. Mutation eliminating mitochondrial leader sequence of methylmalonyl-CoA mutase causes mut° methyl-malonic acidemia; pp. 3147–3150. (Proc Natl Acad Sci USA). - PMC - PubMed

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