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Clinical Trial
. 1995;121(2):126-7.
doi: 10.1007/BF01202225.

Possible lack of full cross-resistance of 5HT3 antagonists; a pilot study

M de Boer  1 , R de Wit, G Stoter, J Verweij
Affiliations
Clinical Trial

Possible lack of full cross-resistance of 5HT3 antagonists; a pilot study

M de Boer et al. J Cancer Res Clin Oncol. 1995.

Abstract

We investigated the potential of cross-over to the serotonin receptor (5HT3) antagonist ondansetron after protection failure with tropisetron. Several cases of complete protection were observed. These limited data suggest that there is an indication for retreatment with a different 5HT3 antagonist after an initial failure to another and also stress the need and relevance for comparative studies between 5HT3 antagonists.

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