Review
doi: 10.1242/jcs.1994.supplement_18.17.
Regulation and function of the MAP kinase cascade in Xenopus oocytes
Affiliations
- PMID: 7883786
- DOI: 10.1242/jcs.1994.supplement_18.17
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Review
Regulation and function of the MAP kinase cascade in Xenopus oocytes
J Cell Sci Suppl.
1994.
Abstract
In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.
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