[Ways of finding inhibitors of HIV reproduction among nucleotides]

Abstract

In spite of continuous broad search for inhibitors of HIV reproduction among new nucleosides, there seems to be a certain crisis in the problem. One of the probable solutions could be based on the investigation of nucleotide and/or nucleoside 5'-triphosphates with modified carbohydrate and phosphate residues. The review analyzes the current state of the problem, examining of such types of compounds in cell-free systems with DNA polymerases and in HIV-infected cell cultures. The known data on the stability and metabolism of such compounds in cell cultures as well as in human serum are also analyzed.