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. 1978 Jun;69(3):423-6.

Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats

Y Hiasa, M Ohshima, T Ohmori, Y Murata
  • PMID: 78868

Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats

Y Hiasa et al. Gan. 1978 Jun.

Abstract

Studies were made on the effect of 0.06% alpha-benzene hexachloride (alpha-BHC) on hepatic changes, including development of hepatomas, in rats treated with 0.025% 2-fluorenylacetamide (2-FAA) at the same time. alpha-BHC inhibited the induction of hepatocellular carcinomas and oval cells infiltration in rats treated with 2-FAA for 5 months. However, it did not inhibit induction of hyperplastic nodules, it induced liver adenocarcinomas in 4 of 11 rats, and it caused remarkable cyst formation in the liver of rats treated with 2-FAA.

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