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. 1994 Nov;12(15):1419-22.
doi: 10.1016/0264-410x(94)90151-1.

Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

E A DeVelasco  1 , H A Dekker, P Antal, K P Jalink, J A van Strijp, A F Verheul, J Verhoef, H Snippe
Affiliations

Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

E A DeVelasco et al. Vaccine. 1994 Nov.

Abstract

The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

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