Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1976 Oct;3(5):883-9.
doi: 10.1111/j.1365-2125.1976.tb00642.x.

Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect

G M Pacifici, M Nardini, P Ferrari, R Latini, C Fieschi, P L Morselli
Clinical Trial

Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect

G M Pacifici et al. Br J Clin Pharmacol. 1976 Oct.

Abstract

Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady-state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half-lives varied from 10-28.5 h with an apparent VD of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.

PubMed Disclaimer

References

    1. J Pharm Pharmacol. 1974 Dec;26 Suppl:81P-82P - PubMed
    1. JAMA. 1969 May 19;208(7):1168-70 - PubMed
    1. Lancet. 1970 Jul 18;2(7664):154-5 - PubMed
    1. Lancet. 1970 May 30;1(7657):1127-9 - PubMed
    1. Lancet. 1970 Sep 12;2(7672):566 - PubMed

LinkOut - more resources