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. 1976 Sep;34(3):233-8.
doi: 10.1038/bjc.1976.157.

Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes

M Giovarelli, P M Comoglio, G Forni
Free PMC article

Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes

M Giovarelli et al. Br J Cancer. 1976 Sep.
Free PMC article

Abstract

Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth.

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