Review
doi: 10.1016/0167-5699(95)80090-5.
Human herpesvirus 6 in AIDS
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- PMID: 7888069
- DOI: 10.1016/0167-5699(95)80090-5
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Review
Human herpesvirus 6 in AIDS
Immunol Today.
1995 Feb.
Abstract
Multiple lines of clinical and experimental evidence suggest that human herpesvirus 6 (HHV-6) may act as an accelerating factor in the natural history of human immunodeficiency virus (HIV) infection. Although, in common with HIV, HHV-6 has a primary tropism for CD4+ T cells, its potential effects on the immune system are broader. For instance, HHV-6 can also infect and kill CD8+ T cells, natural killer cells and mononuclear phagocytes. Here, Paolo Lusso and Robert Gallo suggest that understanding the immunopathogenic role of HHV-6 in the course of HIV infection may shed new light on the complex mechanisms of disease progression in AIDS.
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