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. 1994 Aug-Dec;9(1-3):253-8.
doi: 10.1007/BF02816124.

Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice

M L Cordero  1 , J G Ortiz, G Santiago, A Negrón, J A Moreira
Affiliations

Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice

M L Cordero et al. Mol Neurobiol. 1994 Aug-Dec.

Abstract

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminotransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate aminotransferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA uptake is decreased in cortex, midbrain, and pons medulla. Previous studies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SP) mice. Glutamate Umax by System 1 is significantly decreased in these mice, whereas the Umax value for System 2 is significantly increased in the epileptic mice.

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