Review
doi: 10.1016/0966-842x(94)90651-3.
Survival of the Q fever agent Coxiella burnetii in the phagolysosome
Affiliations
- PMID: 7889323
- DOI: 10.1016/0966-842x(94)90651-3
Item in Clipboard
Review
Survival of the Q fever agent Coxiella burnetii in the phagolysosome
Trends Microbiol.
1994 Dec.
Abstract
The Q fever agent, Coxiella burnetii, thrives in the acidic environment of the phagolysosome of the host cell. How this obligate intracellular agent manages to survive within this hostile milieu is unknown; however, several of its enzymes may eliminate or prevent the formation of toxic oxygen metabolites by the host cell. Also implicated as virulence factors are its surface lipopolysaccharide and plasmids.
Similar articles
-
Coxiella burnetii Lipopolysaccharide: What Do We Know?Int J Mol Sci. 2017 Nov 23;18(12):2509. doi: 10.3390/ijms18122509. Int J Mol Sci. 2017. PMID: 29168790 Free PMC article. Review.
-
Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.J Immunol. 2004 Mar 15;172(6):3695-703. doi: 10.4049/jimmunol.172.6.3695. J Immunol. 2004. PMID: 15004173
-
Acid phosphatase activity in Coxiella burnetii: a possible virulence factor.Infect Immun. 1993 Oct;61(10):4232-9. doi: 10.1128/iai.61.10.4232-4239.1993. Infect Immun. 1993. PMID: 8406811 Free PMC article.
-
Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii.Proc Natl Acad Sci U S A. 1981 May;78(5):3240-4. doi: 10.1073/pnas.78.5.3240. Proc Natl Acad Sci U S A. 1981. PMID: 6942430 Free PMC article.
-
Life on the outside: the rescue of Coxiella burnetii from its host cell.Annu Rev Microbiol. 2011;65:111-28. doi: 10.1146/annurev-micro-090110-102927. Annu Rev Microbiol. 2011. PMID: 21639786 Review.
Cited by
-
Survival of Tropheryma whipplei, the agent of Whipple's disease, requires phagosome acidification.Infect Immun. 2002 Mar;70(3):1501-6. doi: 10.1128/IAI.70.3.1501-1506.2002. Infect Immun. 2002. PMID: 11854238 Free PMC article.
-
Entry and survival of Leishmania amazonensis amastigotes within phagolysosome-like vacuoles that shelter Coxiella burnetii in Chinese hamster ovary cells.Infect Immun. 1995 Sep;63(9):3502-6. doi: 10.1128/iai.63.9.3502-3506.1995. Infect Immun. 1995. PMID: 7642284 Free PMC article.
-
Engineering Protein Nanoparticles Functionalized with an Immunodominant Coxiella burnetii Antigen to Generate a Q Fever Vaccine.Bioconjug Chem. 2023 Sep 20;34(9):1653-1666. doi: 10.1021/acs.bioconjchem.3c00317. Epub 2023 Sep 8. Bioconjug Chem. 2023. PMID: 37682243 Free PMC article.
-
The Prevalence of Coxiella burnetii in Hard Ticks in Europe and Their Role in Q Fever Transmission Revisited-A Systematic Review.Front Vet Sci. 2021 Apr 26;8:655715. doi: 10.3389/fvets.2021.655715. eCollection 2021. Front Vet Sci. 2021. PMID: 33981744 Free PMC article.
-
Epidemiological study of Q fever in humans, ruminant animals, and ticks in Cyprus using a geographical information system.Eur J Clin Microbiol Infect Dis. 2006 Sep;25(9):576-86. doi: 10.1007/s10096-006-0170-7. Eur J Clin Microbiol Infect Dis. 2006. PMID: 16915398
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
