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. 1994 Sep;45(3):193-8.

cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32

A Merckelbach  1 , S Hasse, R Dell, A Eschlbeck, A Ruppel
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  • PMID: 7899786

cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32

A Merckelbach et al. Trop Med Parasitol. 1994 Sep.

Abstract

Sequences of three cDNAs of Schistosoma japonicum are presented. Two of them code for the antigens Sj32 (hemoglobinase) and cathepsin B. The third clone represents a mutant derivative of the cathepsin B gene. The DNA and amino acid sequences are compared to their homologues from S. mansoni. The mutant cathepsin B, in which the Cys29 in the active center is replaced by Ser, is discussed with respect to a possible function.

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