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Clinical Trial
. 1993 Aug;42(2):131-5.
doi: 10.1016/0020-7292(93)90626-8.

Intravesical formalin for hemorrhagic cystitis following irradiation of cancer of the cervix

A K Dewan  1 , G M Mohan, R Ravi
Affiliations
Clinical Trial

Intravesical formalin for hemorrhagic cystitis following irradiation of cancer of the cervix

A K Dewan et al. Int J Gynaecol Obstet. 1993 Aug.

Abstract

Objective: To determine the effectiveness of intravesical formalin instillation in hemorrhagic cystitis following irradiation of cancer of the cervix.

Method: Records were reviewed for 35 patients with hemorrhagic radiation cystitis who underwent treatment with 1% (n = 22), 2% (n = 10), and 4% formalin (n = 4), using Fair's technique.

Result: Complete response was seen in 31 patients (89%) and partial response in 3 patients (8%) after a single instillation. Minor complications were seen in 19 patients (54%). Major complications occurred in 11 patients (31%), with 5 cases requiring subsequent urinary diversion. One patient died of persistent bleeding and probable formalin toxicity. Hematuria recurred in 7 patients achieving complete response at a mean period of 8 months after treatment. A 1% solution was as effective in controlling hematuria as higher concentrations and was associated with significantly less morbidity.

Conclusion: Intravesical instillation of 1% formalin is an effective treatment for intractable hematuria secondary to radiation cystitis.

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