Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Oct 29;36(22):3293-9.
doi: 10.1021/jm00074a010.

N-substituted dibenzoxazepines as analgesic PGE2 antagonists

E A Hallinan  1 , T J Hagen, R K Husa, S Tsymbalov, S N Rao, J P vanHoeck, M F Rafferty, A Stapelfeld, M A Savage, M Reichman
Affiliations

N-substituted dibenzoxazepines as analgesic PGE2 antagonists

E A Hallinan et al. J Med Chem. .

Abstract

8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide (1, SC-19220) has been previously reported by us and others to be a PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activities. Analogs of SC-19220, in which the acetyl moiety has been replaced with pyridylpropionyl groups and their homologs, have been synthesized as illustrated by compounds 13 and 29. These and other members of this series have been shown to be efficacious analgesics and PGE2 antagonists of the EP1 subtype. This report discusses the structure activity relationships within this series.

PubMed Disclaimer

Substances

LinkOut - more resources