Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Nov-Dec;50(6):408-11.
doi: 10.1159/000227220.

Expression of the c-erbB2 proto-oncogene in male breast carcinoma: lack of prognostic significance

N Blin  1 , I Kardaś, C Welter, J Ryś, A Niezabitowski, J Limon, G Seitz
Affiliations

Expression of the c-erbB2 proto-oncogene in male breast carcinoma: lack of prognostic significance

N Blin et al. Oncology. 1993 Nov-Dec.

Abstract

Increase of gene activity of the proto-oncogene erbB2 which codes for the transmembrane kinase receptor p185erbB2 has been observed in > 30% of female breast and gynecological carcinomas. This overexpression was shown to be correlated with poor prognosis. We have investigated 38 samples of carcinomas of the male breast for p185erbB2 expression by using tumor thin sections and a monoclonal antibody. The immunostaining was compared to clinical data to assess a possible prognostic value of this parameter. Although most cases were immunopositive (36/38), no correlation to tumor grading and survival spans was notable. Therefore, erbB2 activity fails to add a new prognostic parameter in male breast carcinomas.

PubMed Disclaimer

Publication types

MeSH terms